Optimal Design Report

Optimal Design Report

An Efficient Bayesian Optimal Design for Logistic Model

Consider a Bayesian optimal design with many support points which poses the problem of collecting data with a few number of observations at each design point. Under such a scenario the asymptotic property of using Fisher information matrix for approximating the covariance matrix of posterior ML estimators might be doubtful. We suggest to use Bhattcharyya matrix in deriving the information matri...

OPTIMAL DESIGN OF TUNNEL SUPPORT LINING USING MCBO ALGORITHM

In this paper, a systematic approach is presented for optimal design of tunnel support lining using two-dimensional finite element analysis models of soil-structure interaction developed in ABAQUS software and the Modified Colliding Bodies Optimization (MCBO) algorithm implemented in MATLAB environment. This approach is then employed to study the influence of variable geometrical and geo-mechan...

Optimal Design # 17 Report Development of a Pulsatile Left Heart Simulator

Formulation and Optimization of Captopril Sublingual Tablet Using D-Optimal Design Sublingual Tablet Using D-Optimal Design

The objective of the current study was to develop and optimize a sublingual tablet formulation of captopril which is an effective drug in the treatment of hypertension. Captopril containing tablets were prepared by direct compression method using different ingredients such as polyvinyl pyrrolidone, starch 1500, sodium starch glycolate and lactose (independent variables) and magnesium stearate, ...